Safety scientists must work across heterogeneous sources and disconnected silos:
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Public sources: DrugBank, PubChem/BioAssay, Tox21, FAERS, VigiBase
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Licensed translational safety content: e.g., OFF-X
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Internal data: preclinical tox studies, safety pharmacology, nonclinical reports, safety narratives
Different schemas, identifiers, and taxonomies make it slow to answer fundamental questions like:
Which targets have signals of organ toxicity? Has this pathway been linked to past AEs? What mechanisms connect this assay hit to downstream phenotypes?
The result: decisions wait on integration, and critical insights surface too late.
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