Case Study

Unifying forces in Alzheimer's research: PRISMA Consortium & DISQOVER

PRISMA consortium using ONTOFORCEs DISQOVER platform (2)

Industry
Healthcare, Research, and Technology

Location
Belgium

The PRISMA consortium (Polygenic Risc scoring and deep-Immunophenotyping Strategy to Master Alzheimer's disease), kicked off in 2020, and was founded with the goal to push Alzheimer’s disease into the field of personalized medicine.

By combining R&D and clinical care, the project also aims to create a unique ecosystem for Alzheimer clinical trials in Belgium’s Flanders.

Bringing together different partners from diverse disciplines, both research and industry, the PRISMA consortium is made up of six partners: VIB, imec, KU Leuven, ONTOFORCE, reMYND, and Hict.

Use cases

In-Vivo

Target Identification

The challenge

By joining the PRISMA consortium and sharing the power of the DISQOVER platform, ONTOFORCE is proud to be playing a pivotal role in advancing the landscape of precision medicine for Alzheimer's disease.

Data is the lifeblood of scientific and medical research. However, collecting, analyzing, and sharing vast amounts of data is often fraught with challenges, from interoperability issues to accessibility concerns.

This is where ONTOFORCE's DISQOVER platform supported the PRISMA consortium.

The outcome

The ability to link research data with publicly available knowledge and data was identified by the PRISMA consortium as a need for the project. The DISQOVER platform enables this ability and has been an effective tool for connecting public data and data from the different stakeholders in academia and industry within the project.

Additionally, ONTOFORCE’s data team creates and maintains remote data subscription (RDS) packages, which are domain-specific data sets compiled from top public data sources tailored to the use of DISQOVER. These packages can be retrieved and ingested into the platform, providing users with the flexibility to make data integration choices based on their use cases so they can optimally use and explore data.

The target identification RDS package has been perfectly suited for the research being conducted in the PRISMA project and the extension of the RDS technology has allowed for easier data sharing between consortium partners. On top of this, the extension of the DISQOVER plugin architecture has enabled connection with downstream applications, which has facilitated further data analysis and collaboration among partners.

Additionally, the plugin architecture has permitted for a customized search capability tailored for PRISMA researchers.

Tine Geldof Senior Data Solution Specialist
ONTOFORCE

The successful implantation of streamlining data collection, integration, sharing, and analysis through the DISQOVER platform has led to enhanced collaboration, improved efficiency, and valuable insights in the project.

Looking ahead after finalizing the PRISMA project

In 2024 the PRISMA project embarked in its final year. The consortium’s work has generated valuable insights, not only to improve diagnosis but also to support the development of novel treatments and monitoring approaches. While the project itself has finished, its outcomes live on through the continued work of each partner, who are now building on the knowledge and tools developed within PRISMA.

Each partner has outlined their next steps, which collectively contribute to advancing our understanding of AD and related disorders, read about them here.

In this regard, ONTOFORCE applies insights gained during PRISMA to strengthen association data and scoring methods, extending these learnings to other indications. Experience with reMYND’s data also enriches ONTOFORCE’s role in supporting R&D and early clinical development use cases.

You can learn more about the PRISMA consortium and its collaboration with a.o. ONTOFORCE here.

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Unifying forces in Alzheimer's research: PRISMA Consortium & DISQOVER

Use cases

The challenge

The outcome

The successful implantation of streamlining data collection, integration, sharing, and analysis through the DISQOVER platform has led to enhanced collaboration, improved efficiency, and valuable insights in the project.

Looking ahead after finalizing the PRISMA project

Get the full case study

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